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Experimental work has associated Epithalon with modulation of genes such as: CD5 linked to immune cell differentiation and adaptive immune responses IL-2 involved in T-cell regulation and broader white blood cell signaling MMP2 associated with extracellular matrix remodeling, collagen dynamics, and tissue repair Tram1 related to protein processing and transport Arylalkylamine-N-acetyltransferase (AANAT) a key enzyme in melatonin synthesis pCREB-related targets transcription factors involved in circadian signaling and potentially anti-neoplastic pathways Telomerase-associated components consistent with observations on telomere biology These gene-level interactions position Epithalon as a useful tool compound for studying how small peptides might influence transcriptional regulation in immune, connective, circadian, and genomic-maintenance pathways

Acknowledgements We acknowledge the support of the staff of the Pennsylvania State University College of Medicine Clinical Research Center and Investigational Pharmacy

The outcome of this study followed the delivery of the cell culture with Epithalon

These purified HBs demonstrated robust self-renewal capacity, expanding in a small-molecule-defined medium (ACDFSV) for over 20 passages without losing their proliferative capacity or characteristic morphology

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